Tools and Services for repeatable Connectomics

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scalable minds' deep learning AI platform Voxelytics enables an automated reliable reconstruction of neural connections from raw EM data over segmented neurons to finished Connectome matrices.
Our services offer an accessible and repeatable process for neuron reconstruction and synapse detection using state-of-the-art Machine Learning algorithms. We collaborate closely with your group in order to get the most out of your data.
We offer WEBKNOSSOS as an easy-to-use collaboration tool for terabyte-scale 3D datasets. Easily and safely share datasets with the team and external collaborators. Annotate skeletons or volumes using efficient manual tools. Explore and review automatic analysis results.

Solutions

Raw image data from the Max Planck Institute for Brain Research

Neuron Segmentation

    Segmentation with Voxelytics● Neuron Reconstruction● Axons, Dendrites, and Synapse Reconstruction● Mitochondria and Vesicle Detection● Custom AI Models
    Optimized for 3D Electron Microscopy(SBEM, SS-TEM, MultiSEM, FIB-SEM)
    Scales from gigabyte-sized to petabyte-sized datasets
    Data management & online collaborative workflows with WEBKNOSSOS

3D Dataset Alignment

    3D tile stitching and registration
    Contrast normalization and gradient correction
    Dynamic mesh deformations
    Optimized for 3D Electron Microscopy(SBEM, SS-TEM, MultiSEM, FIB-SEM)
    Scales to terabyte-scale datasets

                      Raw image data from the Francis Crick Institute

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Connectome Reconstruction

    Automated connectome reconstruction including● Axons● Dendrites● Synapses
    Agglomeration of over-segmented processes
    Heuristics for fixing merged processes
    Interactive Connectome Viewer
    Data management & online collaborative workflows with WEBKNOSSOS

Dataset Management

Use WEBKNOSSOS to view, annotate, and collaboratively work on exploring your datasets. Optimized for 2D and 3D imaging data. Tightly integrated with all Voxelytics analysis tools.

    Data management & online collaborative workflows with WEBKNOSSOS
    Scales from gigabyte-sized to petabyte-sized datasets
    Hosted and On-Premise solutions
    Ready for large Scientific Computing clusters
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Examples

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Dense neuron segmentation of mouse layer 4 somatosensory cortex 

Full dense neuron instance segmentation using modified U-Nets and hierarchical agglomeration. Read blog article.

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Synapse, vesicle, and mitochondria detection in cortex

CNN-based segmentation of all synapses, vesicles, and mitochondria in preparation for synaptic connectivity mapping.

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Axon and dendrite classification

Integrate semantic segmentation of neuron sub-types (axon, dendrite, glia, etc) into the agglomeration to prevent merger error based on prior biological knowledge.

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Want to work with us?

Schedule an introductory video call to learn more about our technology and discuss your use cases with us.

  • Quantum CEO & our partners
  • Quantum CEO & our partners
  • Quantum CEO & our partners